Evaluation of Clinically Effective Doses of Triamcinolone Acetonide for Intralesional Injection in Oral Lichen Planus
박수현, 이해옥, 주혜민, 이지연, 전혜미, 옥수민, 안용우, 정성희,
소속 상세정보
박수현 ( Park Su-Hyeon ) - Pusan National University School of Dentistry Department of Oral Medicine
이해옥 ( Lee Hae-Ohk ) - Pusan National University School of Dentistry Department of Oral Medicine
주혜민 ( Ju Hye-Min ) - Pusan National University School of Dentistry Department of Oral Medicine
이지연 ( Lee Ji-Yeon ) - Pusan National University School of Dentistry Department of Oral Medicine
전혜미 ( Jeon Hye-Mi ) - Pusan National University Hospital Department of Oral Medicine
옥수민 ( Ok Soo-Min ) - Pusan National University School of Dentistry Department of Oral Medicine
안용우 ( Ahn Yong-Woo ) - Pusan National University School of Dentistry Department of Oral Medicine
정성희 ( Jeong Sung-Hee ) - Pusan National University School of Dentistry Department of Oral Medicine
Abstract
Purpose: The aim of this study was to evaluate the optimal doses of intralesional triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP).
Methods: A randomized clinical trial was performed. Sixty-two lesions of OLP were received 12 mg (group A) or 20 mg (group B) of TA intralesionally weekly for 2 weeks. Subjective symptoms, lesion size, favorable conversion of clinical subtypes, and clinical response were evaluated at weeks 0, 1, 2, and 4.
Results: After two consecutive injections of TA, group B showed significant reduction in burning sensation and reticular area (p<0.01). Favorable conversion and complete response were greater in group B. Mild oral candidiasis was developed in group B (10.7%).
Conclusions: A 20-mg injection of TA was much more effective compared with 12-mg injection of TA in the treatment of OLP.
키워드
Intralesional injections; Oral lichen planus; Triamcinolone acetonide
원문 및 링크아웃 정보
등재저널 정보